Hausdorff Forum February 10, 2017 - 14:15

Location: Lipschitz-Saal, Endenicher Allee 60

14:15 Markus M. Nöthen, Institute of Human Genetics (Bonn): Genomic approaches as a basis for understanding multifactorial diseases

The application of systematic genetic methods has led to major breakthroughs in our understanding of the molecular underpinnings of multifactorial diseases. Despite these successes, most genetic variants still await identification. This is being addressed by the expansion of datasets and the application of new sequencing methods to obtain a more complete picture of the variants in the human genome. To reflect the complexity of the development of a multifactorial disease, however, systematic approaches involving complementary methodologies are necessary. In applying such approaches, the integration of different data layers (e.g. genomic, transcriptomic, phenotypic data) with bioinformatics and systems biology methods plays a key role. The concepts will be illustrated by studies into the molecular basis of psychiatric disorders.

15:15-15:45 Tea

15:45 Alois Kneip, Department of Economics (Bonn): Methods for analyzing functional data

Functional data analysis deals with statistical inference in situations where data represent samples of random functions. The talk concentrates on functional regression as well as on structural analysis using so-called registration methods. Potential applications to gene expression data are discussed.