Hausdorff Forum - January 15, 2016 - 14h

Location: room no. 0.008

Hannah Mayer (Bonn, IAM): A stochastic, individual-based model for immunotherapy of cancer

We propose an extension of a standard stochastic, individual-based model in population dynamics which broadens the range of biological applications. The new setup is illustrated by modelling various phenomena arising in immunotherapy for malignant tumours. On the one hand, we show that the interplay of genetic mutations and phenotypic switches on different timescales as well as the occurrence of metastability phenomena raise new mathematical challenges. On the other hand, we argue why understanding purely stochastic events may help to understand the resistance of tumours to various therapeutic approaches and may have non-trivial consequences on tumour treatment protocols.

Waldemar Kolanus (Bonn, LIMES): Cellular migration routes during an immune response

The vast majority of immune cells in vertebrates (backboned animals) are motile, i.e. they are able to move in and out of organs in apparently complex patterns, both at the healthy state and, particularly, in the course of pathogenic challenges. The talk will attempt to describe the current state of our understanding of immune cell dynamics at various levels, including an introduction to the mechanisms of chemotaxis (cellular movement towards (bio)chemical substances) and an overview of the molecular machineries involved in the organismic re-distribution of immune cells on a more systemic level. The presentation will also address some of the important open questions in understanding the significance of immune cell motility patterns and the methodologies involved in solving them.